A recent study reveals that individuals who discontinue popular weight-loss injections like semaglutide or tirzepatide can put back on lost weight far faster than those who end conventional lifestyle regimens.
Research printed in a major health publication shows that while overweight individuals often shed a large proportion of their body weight while undergoing treatment, the weight returns at an average rate of nearly a kilo each month upon discontinuation.
"People buying such drugs must be informed of the risk of quick weight regain when the medication concludes," cautioned expert Dr. Susan Jebb.
Such speed of recovery suggests a reversion to starting weight in about one and a half years.
Comparing Therapies
The research, which reviewed 37 of trials involving over 9,000 of patients, contrasted the results of GLP-1 agonists with conventional dieting.
Researchers note that individuals who lose weight through lifestyle changes alone usually see a more gradual weight regain—around 100 grams monthly—post-intervention.
The Reason for the Rapid Rebound
Nutrition scientists propose the way of the injections explains the amplified regain.
The injections copy a natural hormone called GLP-1, which moderates feelings of fullness.
"Long-term administration of the hormone levels several times higher than normal could lead to the system to generate a reduced amount of its own natural GLP-1, and could reduce sensitivity to its effects," noted Dr. Adam Collins, a nutrition expert.
"Stopping of this GLP-1 'fix' leads to hunger is uncontrolled, making excessive eating a significant risk."
A Chronic Issue?
Health authorities advise the injections for people with weight-linked health risks, accompanied by prescribed lifestyle changes.
Many experts say that, considering the high risk of relapse, the therapy is often life-long.
This opinion is supported by pharmaceutical companies, who state that the results "emphasize the chronic character of obesity," akin to managing diseases like diabetes.
User Experiences
Users who have discontinued the medication explain a sudden return of cravings.
"I experienced a trigger that goes on and you're instantly ravenous," said an individual.
The struggle is worsened if patients have not developed lasting dietary or behavioural changes during therapy.
Widespread Use
Recent estimates indicate that millions of people in the UK have tried weight-loss jabs in the past year, with interest remaining high.
- Adoption is more common among females compared to men.
- The middle-aged age group shows the greatest usage rates.
- Many obtain the medications through private healthcare rather than public health services.
Ultimately, experts caution that while these medications are powerful tools for shedding pounds, they are not a permanent solution and long-term success likely depends on ongoing lifestyle support.
